I have spent considerable time in the decades since college graduation contemplating my next move. Whether looking for advancement (greater challenge, more senior title, higher pay), relocating for family, returning to work after maternity leave, or considering sole proprietorship, I have continually found or made opportunities that have been rewarding and educational.
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In and of itself, being ambitious is culturally accepted in the U.S., if not downright encouraged. It goes hand in hand with the norm in our present day society to expect upward career mobility (while recognizing that a few lateral steps periodically may be necessary to give us a better position from which to launch to the next level).